Prochlorperazine in Anxiety
نویسندگان
چکیده
Seventy patients suffering from primary anxiety state were selected for this clinical trial. They were randomly assigned to Prochlorperazine (Group I) and other drugs eg., Chlordiapoxide etc. (Group II). Hamilton's anxiety scale was employed to rate the anxiety. With the 4 weeks of therapy there was significant fall in score in both the groups of patients but the fall in score is more in Group I cases as compared to Group II (t = 11.5, df= 68, P < 0.001). The reduction in score (less than 10) and clinical improvement (medium to optimal improvement) was significantly more and faster in Group I (85%) cases as compared to Group II (70%) cases (χ(2) = 5.225, df = 1, P < 0.02). The side effects were least in Group I cases.Prochlorperazine (Stemetil) has given a significant anxiolytic effect without adversly affecting the mental function. In the dosage used prochlorperazine was free from the side effects and can be effectively employed in the management of anxiety.
منابع مشابه
Oral granisetron for the prevention of acute late onset nausea and vomiting in patients treated with moderately emetogenic chemotherapy.
PURPOSE To demonstrate the efficacy of oral granisetron 1 mg twice daily for the prevention of late onset nausea and vomiting after moderately emetogenic chemotherapy that includes cyclophosphamide, carboplatin, or doxorubicin. METHODS Prior to chemotherapy, patients were stratified by gender and randomized to receive oral granisetron (1 mg tablet twice daily) or prochlorperazine (10 mg susta...
متن کاملThe effects of two anti-vertigo drugs (betahistine and prochlorperazine) on driving skills.
1. The effects of betahistine 72 mg three times daily, prochlorperazine 5 mg three times daily and placebo taken for 3 days before testing were compared on two actual driving tasks (weaving and gap estimation) and two psychomotor tasks (reaction time and kinetic visual acuity) in normal subjects in a double-blind prospectively randomised cross-over study. 2. The psychomotor effects of betahisti...
متن کاملProchlorperazine-Induced Hemidystonia Mimicking Acute Stroke
Prochlorperazine is frequently used in the treatment of refractory nausea and migraines. Known side effects include extrapyramidal symptoms such as akathisia and dystonia. We report a pregnant patient taking prochlorperazine for hyperemesis gravidarum who developed hemidystonia, which triggered an acute code stroke response from prehospital, emergency medicine and neurology providers. We suspec...
متن کاملVoltammetric Determination of Prochlorperazine and Ethopropazine Using a Gold Electrode Modified with Decanethiol SAM
The voltammetric behavior of prochlorperazine and ethopropazine at a decanethiol (DEC) self-assembled monolayer (SAM) modified gold electrode (DEC/Au) has been studied. It was observed that prochlorperazine exhibited an anodic peak at about 0.60 V (vs SCE), while ethopropazine exhibited two anodic peaks at about 0.49 V and 0.58 V on DEC/Au in pH 10 sodium carbonate buffer. This was due to their...
متن کاملAntibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine.
The antipsychotic drug prochlorperazine was screened in vitro for possible antimicrobial property against 157 strains of bacteria, belonging to gram positive and gram negative genera. The minimum inhibitory concentration (MIC) of prochlorperazine was determined by agar dilution method, which ranged from 25 to 200 microg/ml with respect to most of the strains. Based on such findings, a further s...
متن کامل